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Obviously, a growing body of preclinical evidences suggests that the induction of lipid peroxidation by inhibiting system x c - might be an effective therapeutic strategy to clear cancer cells and prevent the acquired resistance to several cancer drugs, such as lapatinib, dabrafenib and vemurafenib (Table S1) [228, 261, 262]

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Cryo-EM data for the wt PV2-CP17 complex were collected at 300 kV on a Titan Krios (Thermo Fisher Scientific) equipped with a K3 DED and GIF Quantum energy filter (Gatan) at the electron Bio-Imaging Centre, Diamond Light Source, UK