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Mechanism with Specific Numbers The target is nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (MNA) and S-adenosylhomocysteine (SAH)
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More methionine is needed to deactivate estrogens when estrogen levels are elevated to prevent the increased estrogens from reducing the flushing of fat from the liver and increasing cholesterol levels
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